Research Topics

  • Understanding and manipulating tolerance to multiple stresses in the cell factory Saccharomyces cerevisae;
  • Multidrug/multixenobiotic resistance (MDR/MXR) membrane transporters;
  • Yeast toxicogenomics;
  • Functional analysis of homologous transporters in the plant model Arabidopsis thaliana and design of plants resistant to agricultural stresses (in collaboration).

Selected Publications

Godinho CP, Dias PJ, Ponçot E, and Sá-Correia I (2018) The paralogous genes PDR18 and SNQ2, encoding multidrug resistance ABC transporters, derive from a recent duplication event, PDR18 being specific to the Saccharomyces genus. Frontiers in Genetics in press.doi: 10.3389/fgene.2018.00476

Godinho CP, Prata CS, Pinto SN, Cardoso C, Bandarra NM, Fernandes F, and Sá-Correia I (2018) Pdr18 is involved in yeast response to acetic acid stress counteracting the decrease of plasma membrane ergosterol content and order. Scientific Reports 8(1):7860. doi: 10.1038/s41598-018-26128-7.

Teixeira MC, Monteiro PT, Palma M, Costa C, Godinho CP, Pais P, Cavalheiro M, Antunes M, Lemos A, Pedreira T, and Sá-Correia I (2018) YEASTRACT: an upgraded database for the analysis of transcription regulatory networks in Saccharomyces cerevisiae. Nucleic Acids Research 46(D1):D348-D353. doi: 10.1093/nar/gkx842.

Remy E, Niño-González M, Godinho CP, Cabrito TR, Teixeira MC, Sá-Correia I, and Duque P (2017) Heterologous expression of the yeast Tpo1p or Pdr5p membrane transporters in Arabidopsis confers plant xenobiotic tolerance, Scientific Reports 7(1):4529. doi: 10.1038/s41598-017-04534-7.

Vasco MS, Alves LC, Corregidor V, Correia D, Godinho CP, Sá-Correia I, Bettiol A, Watt F, and Pinheiro T (2017) 3D map distribution of metallic nanoparticles in whole cells using MeV ion microscopy, Journal of Microscopy, doi: 10.1111/jmi.12561.

Godinho CP, Mira NP, Cabrito TR, Teixeira MC, Alasoo K, Guerreiro JF, and Sá-Correia I (2017) Yeast response and tolerance to benzoic acid involves the Gcn4- and Stp1- regulated multidrug/multixenobiotic resistance transporter Tpo1. Applied Microbiology and Biotechnology 101: 5005. doi:10.1007/s00253-017-8277-6.

Teixeira MC, Godinho CP, Cabrito TR, Mira NP, and Sá-Correia I (2012) Increased expression of the yeast multidrug resistance ABC transporter Pdr18 leads to increased ethanol tolerance and ethanol production in high gravity alcoholic fermentation, Microbial Cell Factories 11:98. doi: 10.1186/1475-2859-11-98.

Alternative web pages