Research Topics

  • Understanding and manipulating tolerance to multiple stresses in the cell factory Saccharomyces cerevisae;
  • Multidrug/multixenobiotic resistance (MDR/MXR) membrane transporters;
  • Yeast toxicogenomics;
  • Functional analysis of homologous transporters in the plant model Arabidopsis thaliana and design of plants resistant to agricultural stresses (in collaboration).

Selected Publications

Godinho CP, Prata CS, Pinto SN, Cardoso C, Bandarra NM, Fernandes F, Sá-Correia I, Pdr18 is involved in yeast response to acetic acid stress counteracting the decrease of plasma membrane ergosterol content and order, Scientific Reports,(2018), 8(1):7860. doi: 10.1038/s41598-018-26128-7.

Teixeira, M.C., Monteiro, P.T., Palma, M., Costa, C., Godinho, C.P., Pais, P., Cavalheiro, M., Antunes, M., Lemos, A., Pedreira, T. and Sá-Correia, I., YEASTRACT: an upgraded database for the analysis of transcription regulatory networks in Saccharomyces cerevisiae, Nucleic Acids Res, (2018), 46(D1):D348-D353. doi: 10.1093/nar/gkx842.

Remy, E., Niño-González, M., Godinho, C.P., Cabrito, T.R., Teixeira, M.C., Sá-Correia, I., Duque, P., Heterologous expression of the yeast Tpo1p or Pdr5p membrane transporters in Arabidopsis confers plant xenobiotic tolerance, Scientific Reports, (2017), 7(1):4529. doi: 10.1038/s41598-017-04534-7.

Vasco, M.S., Alves, L.C., Corregidor, V., Correia, D., Godinho, C.P., Sá-Correia, I., Bettiol, A., Watt, F., Pinheiro, T., 3D map distribution of metallic nanoparticles in whole cells using MeV ion microscopy, Journal of Microscopy, (2017) doi: 10.1111/jmi.12561.

Godinho, C.P., Mira, N.P., Cabrito, T.R., Teixeira, M.C., Alasoo, K., Guerreiro, J. F., Sá-Correia, I., Yeast response and tolerance to benzoic acid involves the Gcn4- and Stp1- regulated multidrug/multixenobiotic resistance transporter Tpo1, Applied Microbiology and Biotechnology, (2017) 101: 5005. doi:10.1007/s00253-017-8277-6.

Teixeira, M.C., Godinho, C.P., Cabrito, T.R., Mira, N.P., Sá-Correia, I., Increased expression of the yeast multidrug resistance ABC transporter Pdr18 leads to increased ethanol tolerance and ethanol production in high gravity alcoholic fermentation, Microbial Cell Factories(2012) 11:98. doi: 10.1186/1475-2859-11-98.

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