Isabel Sá-Correia

POSITION:Head of the BSRG and Full Professor

Leader of the research theme:Physiological Genomics for Sustainable Biotechnology and Microbial Pathogenesis

E-mail:isacorreia@tecnico.ulisboa.pt

Research Activities

Isabel Sá-Correia research interests are in the fields of Molecular and Cellular Microbiology, Functional and Comparative Genomics and Bioinformatics, and Microbial Biotechnology. Research strategies explore the Physiological Genomics approach to allow a holistic understanding of the complex cellular adaptive responses and tolerance of yeasts and gram-negative bacteria to environmental stresses and other challenges relevant to guide the improvement/control of their activity in Industrial, Agro-Food, Health, and Environmental Biotechnology

Research Team

Education, Postdoctoral training, Titles 

  • BSc in Chemical Engineering, Instituto Superior Técnico (IST), Technical University of Lisbon (UTL), 1975.
  • Post-graduation in Biological Engineering (Molecular Biology), New University of Lisbon/ Advanced Studies of Gulbenkian Institute of Science, 1980.
  • Ph.D. degree in Chemical Engineering (Biotechnology-Biological Sciences) from IST/UTL, 1984. The PhD thesis work was carried out in the Microbiology Laboratory of Gulbenkian Institute of Science in the field of Yeast Biology (adviser: N. van Uden).
  • Postdoctoral studies, as Fulbright Visiting Assistant Professor, in the Dept. Microbiology and Immunology, University of Illinois at Chicago, College of Medicine, Medical Center, Chicago, USA (1985/86) with A. M. Chakrabarty (Molecular Biology of Pseudomonas)
  • “Agregação” (Habilitation) title in Chemical Engineering (Biotechnology/Biological Sciences) from IST/UTL, 1992

Positions and Employment

  • Since 1995 – Full Professor of Biological Sciences atInstituto Superior Técnico (IST), Technical University of Lisbon/Universidade de Lisboa
  • 1975-1995 – Associate Professor, Assistant Professor or Teaching Assistant,  Instituto Superior Técnico, Technical University of Lisbon
  • Since 1993 – Head of the Biological Sciences Research Group, IBB/iBB, IST
  • Since 2013 – Directive Board Member of iBB-Institute for Bioengineering and Biosciences
  • Since 2011 – Vice President of the Department of Bioengineering, IST
  • Since 2013 –Member of the General Council, Universidade de Lisboa
  • Since 2008 – Coordinator of the IST Master’s Program in Biotechnology, IST
  • Since 2008 – Coordinator of the IST Ph.D. program in Biotechnology/Biotechnology and Biosciences, IST
  • 2010-2015 – Coordinator at IST of the Erasmus Mundus Master’s Program in Systems Biology – euSYSBIO
  • Since 2013 – Coordinator of the joint Master’s program in Microbiology, IST in collaboration with the Faculties of Sciences, Medicine and Veterinary Medicine of Universidade de Lisboa
  • Since 2015 – Director of the FCT Ph.D. program BIOTECnico in Biotechnology and Biosciences, IST-iBB (funded by FCT, the Portuguese Foundation for Science and Technology)
  • Since 2015 – Directive Board Member of the FCT funded PhD programme in Applied and Environmental Microbiology (AEM)

Other Experience and Professional Memberships

  • Since 2009 – Coordinator of the evaluation panel “Biochemistry and Biotechnology_University Education" of the Agency for the Evaluation and Accreditation of Higher Education (A3ES, Portugal).
  • Since 2009 – President, Portuguese Society of Microbiology (http://www.spmicrobiologia.pt/)
  • Since 2009 – Member of FEMS (Federation of European Microbiological Societies) Council
  • Since 2013 – Editorial Board Member, Microbial Cell
  • Since 2010 – Editorial Board Member, OMICS: Journal Integrative Biology
  • Since 2007 – Editorial Board Member, FEMS Yeast Research
  • Since 2008 – Associate Editor, J. Biomed. Biotechnol/BioMed Research International
  • Since 2015 – Member of Conselho Nacional de Educação (CNE; National Educational Council), in representation of the research units rated as exceptional or excellent.
  • Since 2015 – Member (corresponding) of Academia das Ciências de Lisboa (Biological Sciences).

Recent Publications

Antunes M, Palma M, Sá-Correia I, Transcriptional profiling of Zygosaccharomyces bailii early response to acetic acid or copper stress mediated by ZbHaa1, Scientific Reports, accepted for publication.

Godinho CP, Prata CS, Pinto SN, Cardoso C, Bandarra NM, Fernandes F, Sá-Correia I, Pdr18 is involved in yeast response to acetic acid stress counteracting the decrease of plasma membrane ergosterol content and order, Scientific Reports8(1):7860, 2018

Palma M, Guerreiro JF, Sá-Correia I. Adaptive response and tolerance to acetic acid in Saccharomyces cerevisiae and Zygosaccharomyces bailii: a physiological genomics perspective. Front Microbiol, 9:274. 2018.

Teixeira MC, Monteiro PT, Palma M, Costa C, Godinho CP, Pais P, Cavalheiro M, Antunes M, Lemos A, Pedreira T and Sá-Correia I (2018), YEASTRACT: an upgraded database for the analysis of transcription regulatory networks in Saccharomyces cerevisiaeNucleic Acids Res, 46(D1), 2018.

Palma M, Münsterkötter M, Peça J, Güldener U and Sá-Correia I, Genome sequence of the highly weak-acid-tolerant Zygosaccharomyces bailii IST302, amenable to genetic manipulations and physiological studies, Fems Yeast Res, 17(4), 2017. 

Guerreiro, J.F., Mira, N.P., Santos, A.X.S., Riezman, H., Sá-Correia, I., Membrane phosphoproteomics of yeast early response to acetic acid: Role of Hrk1 kinase and lipid biosynthetic pathways, in particular sphingolipids, Frontiers in Microbiology, 8:1302, 2017.

Hassan, A.A., Maldonado, R.F., Dos Santos, S.C., Di Lorenzo, F., Silipo, A., Coutinho, C.P., Cooper, V.S., Molinaro, A., Valvano, M.A., Sá-Correia, I. Structure of O-Antigen and Hybrid Biosynthetic Locus in Burkholderia cenocepacia Clonal Variants Recovered from a Cystic Fibrosis Patient, Frontiers in Microbiology, 8:1027, 2017.

Henriques, S.F., Mira, N.P., Sá-Correia, I., Genome-wide search for candidate genes for yeast robustness improvement against formic acid reveals novel susceptibility (Trk1 and positive regulators) and resistance (Haa1-regulon) determinants, Biotechnology and Biofuels, 10: 96, 2017.

Palma, M., Dias, P.J., Roque, F.C., Luzia, L., Guerreiro, J.F., Sá-Correia, I., The Zygosaccharomyces bailii transcription factor Haa1 is required for acetic acid and copper stress responses suggesting subfunctionalization of the ancestral bifunctional protein Haa1/Cup2, BMC Genomics, 18: 75, 2017 (F1000 Prime Recommended Article).

 

All Papers, Book Chapters and Patents

Edition of Books and Book Chapters

Edition of Books:

Sá-Correia, M.C. Teixeira, N.P. Mira, “Book of Abstracts – PYFF6 – 6th Conference on Physiology of Yeasts and Filamentous Fungi“, 2016 (ISBN: 978-989-20-6736-0)

Book chapters:

M.C. Teixeira, P.T.Monteiro, I. Sá-Correia, “Predicting gene and genomic regulation in Saccharomyces cerevisiae, using the YEASTRACT database: a step by step guided analysis", In: Methods in Molecular Biology – Yeast Functional Genomics (Frederic Devaux, Ed), Springer, vol. 1361, 391-404, 2016.

I.Sá-Correia, S. dos Santos, A.Madeira Burkholderia Proteomics: methodologies, challenges, and applications, In: Burkholderia: From Genomes to Functions (ed. Tom Coenye & ‘Eshwar Mahenthiralingam), Horizon Press, 2014.

I.Sá-Correia,  J.F Guerreiro,C. Loureiro-Dias, C. Leão, M. Côrte-Real, ZYGOSACCHAROMYCES In: Encyclopedia of Food Microbiology 2nd Edition, edited by Carl Batt & Mary Lou Tortorello, 2014.

N.P. Mira, M.C. Teixeira, I. Sá-Correia, “Characterization of complex regulatory networks and identification of promoter regulatory elements in yeast: in silico and wet-lab", In: Methods in Molecular Biology – Transcriptional Regulation: Methods and Protocols (Vancura A., Ed), Springer, vol. 809, 27-48, 2012.

T.R. Cabrito, E. Remy, M.C. Teixeira, P. Duque, I. Sá-Correia, “Resistance to herbicides in the model organisms Saccharomyces cerevisiae and Arabidopsis thaliana: the involvement of multidrug resistance transporters", In: Herbicides and Environment (Kortekamp A, Ed), INTECH, Vienna, Austria, 623-640, 2011

T.R. Cabrito, M.C. Teixeira, I. Sá-Correia, “Global adaptive response and resistance to agricultural fungicides: lessons from yeast and phytopathogenic fungi” In: Fungicides: Chemistry, Environmental Impact and Health Effects (Columbus F, Ed), Nova Publishers, New York, USA, p. 228-253 (ISBN: 978-1-60692-631-4).

A.M. Fialho, L.M. Moreira, A.T. Granja, K. Hoffmann, A. Popescu, I. Sá-Correia, “Biotechnology of the bacterial gellan gum: genes and enzymes of the biosynthetic pathway", In: A Portrait of State-of-the-Art Research at the Technical University, (M.S. Pereira, ed.), Springer, Dordrecht, The Netherlands, pp. 233-250, 2007

A.L. Oliveira, A.T. Freitas, I. Sá-Correia, “Bioinformatics: a new approach for the challenges of molecular biology", In: A Portrait of State-of-the-Art Research at the Technical University, (M.S. Pereira, ed.), Springer, Dordrecht, The Netherlands, pp. 295-309, 2007

Sá-Correia, M.C. Teixeira, “As complexas redes de regulação da expressão genética na levedura: abordagens à escala do genoma". In: O Mundo do RNA: Novos Desafios e Perspectivas Futuras(Cecília M. Arraiano, A.M. Fialho, eds), Lidel Edições Técnicas, Lisboa,  p. 223-242, 2007

Sá-Correia, L.M. Moreira and A. M. Fialho, “Engenharia Genética", In:Biotecnologia: Fundamentos e Aplicações, (M. Mota e N. Lima, eds.), Lidel Edições Técnicas, Lisboa, pp. 125-161, 2003

All Papers

2018

Godinho CP, Prata CS, Pinto SN, Cardoso C, Bandarra NM, Fernandes F, Sá-Correia I, Pdr18 is involved in yeast response to acetic acid stress counteracting the decrease of plasma membrane ergosterol content and order, Scientific Reports, accepted for publication.

Cunha JT, Costa CE, Ferraz L, Romaní A, Johansson B, Sá-Correia I, Domingues L, HAA1 and PRS3 overexpression boosts yeast tolerance towards acetic acid improving xylose or glucose consumption: unravelling the underlying mechanisms. Applied Microbiology and Biotechnology, 2018 (accepted for publication)

Palma, M., Guerreiro, J.F., Sá-Correia, I. Adaptive response and tolerance to acetic acid in Saccharomyces cerevisiae and Zygosaccharomyces bailii: a physiological genomics perspective. Frontiers in Microbiology, 9:274, 2018.

Teixeira, M.C., Monteiro, P.T., Palma, M., Costa, C., Godinho, C.P., Pais, P., Cavalheiro, M., Antunes, M., Lemos, A., Pedreira, T. and Sá-Correia, I., YEASTRACT: an upgraded database for the analysis of transcription regulatory networks in Saccharomyces cerevisiae, Nucleic Acids Research, 46(D1), 2018.

 

2017

Guerreiro, J.F., Mira, N.P., Santos, A.X.S., Riezman, H., Sá-Correia, I., “Membrane phosphoproteomics of yeast early response to acetic acid: Role of Hrk1 kinase and lipid biosynthetic pathways, in particular sphingolipids", Frontiers in Microbiology, 8:1302, 2017.

Remy, E., Niño-González, M., Godinho, C., Cabrito, T.R., Teixeira, M.C., Sá-Correia, I., Duque, P., Heterologous expression of the yeast Tpo1p or Pdr5p membrane transporters in Arabidopsis confers plant xenobiotic tolerance, Scientific Reports7(1):4529, 2017.

Hassan, A.A., Maldonado, R.F., Dos Santos, S.C., Di Lorenzo, F., Silipo, A., Coutinho, C.P., Cooper, V.S., Molinaro, A., Valvano, M.A., Sá-Correia, I. Structure of O-Antigen and Hybrid Biosynthetic Locus in Burkholderia cenocepacia Clonal Variants Recovered from a Cystic Fibrosis Patient, Frontiers in Microbiology, 8:1027, 2017.

Palma, M., Münsterkötter, M., Peça, J., Güldener, U., Sá-Correia, I., Genome sequence of the highly weak-acid-tolerant Zygosaccharomyces bailii IST302, amenable to genetic manipulations and physiological studies, Fems Yeast Research, 17(4), 2017. 

Bernardo, R., Cunha, D.V., Wang, C., Pereira, L., Silva, S., Salazar, S.B., Schroeder, M.S., Okamoto, M., Takahashi-Nakaguchi, A., Chibana, H., Aoyoama, T., Sá-Correia, I., Azeredo, J., Butler, G., Mira, N.P., “The CgHaa1-regulon mediates response and tolerance to acetic acid stress in the human pathogen Candida glabrata"G3: Genes, Genomes and Genetics, 7(1):1-18, 2017.

Henriques, S.F., Mira, N.P., Sá-Correia, I., Genome-wide search for candidate genes for yeast robustness improvement against formic acid reveals novel susceptibility (Trk1 and positive regulators) and resistance (Haa1-regulon) determinants, Biotechnology for Biofuels, 10:96, 2017.

Godinho, C.P., Mira, N.P., Cabrito, T.R., Teixeira, M.C., Alasoo, K., Guerreiro, J. F., Sá-Correia, I., “Yeast response and tolerance to benzoic acid involves the Gcn4- and Stp1- regulated multidrug/multixenobiotic resistance transporter Tpo1”, Applied Microbiology and Biotechnology, 101(12):5005-5018, 2017. 

Monteiro, P.T., Pais, P., Costa, C., Manna, S., Sá-Correia, I., Teixeira, M.C., 2017, “The PathoYeastract database: an information system for the analysis of gene and genomic transcription regulation in pathogenic yeasts", Nucleic Acids Research, 45(D1):D597-D603, 2017.

Palma, M., Dias, P.J., Roque, F.C., Luzia, L., Guerreiro, J.F., Sá-Correia, I., The Zygosaccharomyces bailii transcription factor Haa1 is required for acetic acid and copper stress responses suggesting subfunctionalization of the ancestral bifunctional protein Haa1/Cup2, BMC Genomics, 18(1):75, 2017.

Vasco, M.S., Alves, L.C., Corregidor, V., Correia, D., Godinho, C.P., Sá-Correia, I., Bettiol, A., Watt, F., Pinheiro, T. 3D map distribution of metallic nanoparticles in whole cells using MeV ion microscopy. Journal of Microscopy. 267(2):227-236, 2017.

 Swinnen, S.*, Henriques, S.C.F.*, Shrestha, R., Ho, P.W., Sá-Correia, I.**, Nevoigt, E.**, Improvement of yeast tolerance to acetic acid through Haa1 transcription factor engineering: towards the underlying mechanisms, Microbial Cell Factories, 16:7, 2017. (*co-first;**co-correspondent)  

 

2016

Araujo, R., Caramalho, R., Coutinho, C., Sá-Correia, I. SNaPBceBcon: a practical tool for identification and genotyping of Burkholderia cepacia and Burkholderia contaminansJ Clin Microbiol. 2:483-488, 2016.

Cabral, M.G., Pereira, M., Silva, Z., Iria, I., Coutinho, C., Lopes, A., Sá-Correia, I., Videira, P.A., Using dendritic cells to evaluate how Burkholderia cenocepacia clonal isolates from a chronically infected cystic fibrosis patient subvert immune functions, Medical Microbiology and Immunology, accepted for publication.

Ferreira, R.A., Roma-Rodrigues, C., Davies, L.C., Sá-Correia, I., Martins-Dias, S., A quantitative proteomic approach to highlight Phragmites sp. adaptation mechanisms to chemical stress induced by a textile dyeing pollutant, Science of The Total Environment, 573, 788, 2016.

Guerreiro J*, Muir A*, Ramachandran S, Thorner J**, Sá-Correia I**, Sphingolipid biosynthesis upregulation by TOR Complex 2-Ypk1 signaling during yeast adaptive response to acetic acid stress, Biochemical Journal 473(23): 4311-4325, 2016.(*co-first;**co-correspondent)

Guerreiro, J.F., Sampaio-Marques, B., Soares, R., Coelho, A.V., Leão, C., Ludovico, P., Sá-Correia, I., Mitochondrial proteomics of the acetic acid – induced programmed cell death response in a highly tolerant Zygosaccharomyces bailii – derived hybrid strain. Microbial Cell, 3(2): 65-78, 2016.

Maldonado, R., Sá-Correia, I., Valvano, M., Lipopolysaccharide modification in Gram-negative bacteria during chronic infection, FEMS Microbiology Reviews, 40(4): 480-493, 2016.

Moreira, A.S., Lourenço, A.B., Sá-Correia, I., 1H-NMR-based endometabolome profiles of Burkholderia cenocepacia clonal variants retrieved from a cystic fibrosis patient during chronic infection, Frontiers in Microbiology, 7:2024, 2016.

Moreira, A.S., Mil-Homens, D.*, Sousa, S.A.*, Coutinho, C.P.*, Pinto-de-Oliveira, A., Ramos, C.G., dos Santos, S.C., Fialho, A.M., Leitão, J.H., Sá-Correia, I., Variation of Burkholderia cenocepacia virulence potential during cystic fibrosis chronic lung infection. Virulence, doi:10.1080/21505594.2016.1237334 (in press).

2015

Coutinho, C.P., Barreto, C., Pereira, L., Lito, L., Melo Cristino, J., Sá-Correia, I. Incidence of Burkholderia contaminans at a cystic fibrosis centre with an unusually high representation of Burkholderia cepacia during 15 years of epidemiological surveillance. J Med Microbiol. 64(8):927-35, 2015.

Cullen, L., Weiser, R., Olszak, T., Maldonado, R.F., Moreira, A.S., Slachmuylders, L., Brackman, G., Paunova-Krasteva, T.S., Zarnowiec, P., Czerwonka, G., Reilly, J., Drevinek, P., Kaca, W., Melter, O., de Soyza, A., Perry, A., Winstanley, C., Stoitsova, S.R., Lavigne, R., Mahenthiralingam, E., Sá-Correia, I., Coenye, T., Drulis-Kawa, Z., Augustyniak, D., Valvano, M.A., McClean, S., “Phenotypic characterisation of an international Pseudomonas aeruginosa reference panel: Strains of cystic fibrosis origin show less in vivo virulence than non-CF strains", Microbiology, 161(10):1961-77, 2015.

dos Santos, S.C., Sá-Correia, I., “Yeast toxicogenomics: lessons from a eukaryotic cell model and cell factory", Current Opinion in Biotechnology 33:183–191.

Palma, P., Roque, F.C., Guerreiro, J., Mira, N.P., Queiroz, L., Sá-Correia, I., “Search for genes responsible for the remarkably high acetic acid tolerance of a Zygosaccharomyces bailii-derived interspecies hybrid strain", BMC Genomics, 16:1070.

Remy, E., Cabrito, T.R., Baptista, R.A., Teixeira M.C., Sá-Correia, I., Duque, P., “The Major Facilitator Superfamily transporter ZIFL2 modulates cesium and potassium homeostasis in Arabidopsis“, Plant and Cell Physiology, 56 (1), 148-162.

Tyrrell J., Whelan N., Wright C., Sá-Correia I., McClean S., Thomas M., Callaghan M., “Investigation of the multifaceted iron acquisition strategies of Burkholderia cenocepacia“, Biometals, in press, 28 (2), 367-380.

2014

Costa, C., Dias, P.J., Sá-Correia, I., Teixeira, M.C., “MFS multidrug transporters in pathogenic fungi: do they have real clinical impact?", Frontiers in Physiology, 5:197.

de Carvalho, J., Rodrigues, R.M.M., Tomé, B., Henriques, S.F., Mira, N.P., Sá-Correia, I., Ferreira, G.N.M., “Conformational and Mechanical changes of DNA upon transcription factor binding detected by a QCM and transmission line model", Analyst, 139(8): 1847-55.

Dias P.J., Sá-Correia I., “Phylogenetic and syntenic analyses of the 12-spanner drug:H(+) antiporter family 1 (DHA1) in pathogenic Candida species: evolution of MDR1 and FLU1 genes". Genomics, 104(1):45-57.

dos Santos, S.C., Teixeira, M.C., Dias, P.J., Sá-Correia, I., “MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches", Frontiers in Physiology, 5:180.

Mira, N.P., Münsterkötter, M., Dias-Valada, F., Santos, J., Palma, M., Roque, F., Guerreiro, J., Rodrigues, F., Sousa, M.J., Leão, C., Guldener, U., Sá-Correia, I., “The genome sequence of the highly acetic acid-tolerant Zygosaccharomyces bailii derived interspecies hybrid strain ISA1307, isolated from a sparkling wine plant", DNA Research, 21(3):299-313.

Moreira, A.S., Coutinho, C.P., Avezedo, P., Lito, L., Melo-Cristino, J., Sá-Correia, I., “Burkholderia dolosa phenotypic variation during the decline in lung function of a cystic fibrosis patient along 5.5 years of chronic colonization", Journal of Medical Microbiology, 63: 594-601.

Pereira, F.B., Teixeira, M.C., Mira, N.P., Sá-Correia, I., Domingues, L., “Genome-wide screening of Saccharomyces cerevisiae genes required to foster tolerance towards industrial wheat straw hydrolysates", Journal of Industrial Microbiology & Biotechnology, 41: 1753-61.

Remy, E., Cabrito, T.R., Batista, R.A., Hussein, M.A.M., Teixeira, M.C., Athanasiadis, A., Sá-Correia, I., Duque, P., “Intron Retention in the 5’UTR of the Novel ZIF2 Transporter Enhances Translation to Promote Zinc Tolerance in Arabidopsis“, PLOS Genetics, 10(5): e1004375.

Rodrigues, R.M.M., de Carvalho, J., Henriques, S.F., Mira, N.P., Sá-Correia, I., Ferreira, G.N.M., “Transmission Line Model Analysis of Transcription Factors Binding to Oligoduplexes – Differentiation of the Effect of Single Nucleotide Modifications", Analyst, 139(16):3871-4.

Teixeira, M.C., Monteiro, P.T., Guerreiro, J.F., Gonçalves, J.P., Mira, N.P., dos Santos, S.C., Cabrito, T., Palma, M., Costa, C., Francisco, A.P., Madeira, S.C., Oliveira, A.L., Freitas, A.T., Sá-Correia, I., The YEASTRACT database: an upgraded information system for the analysis of gene and genomic transcription regulation in Saccharomyces cerevisiaeNucleic Acids Research, 42: D161-D166.

2013

Costa, C., Pires, C., Cabrito, T.R., Renaudin, A., Ohno, M., Chibana, H., Sá-Correia, I., Teixeira, M.C., 2013, Candida glabrata drug:H+ antiporter CgQdr2 (ORF CAGL0G08624g) confers imidazole drug resistance, being activated by the CgPdr1 transcription factor, Antimicrobial Agents and Chemotherapy, 57(7):3159-67.

Costa, C., Henriques, A.S., Pires, C., Nunes, J., Ohno, M., Chibana, H., Sá-Correia, I., Teixeira, M.C., 2013, The dual role of Candida glabrata Drug:H+ Antiporter CgAqr1 (ORF CAGL0J09944g) in antifungal drug and acetic acid resistance, Frontiers in Microbiology, 4: 170.

De Soyza, A., Hall, A., Mahenthiralingam, E., Drevinek, P., Kaca, W., Drulis-Kawa, Z., Stoitsova, S., Toth, V., Coenye, T., Zlosnik, J., Burns, J., Sá-Correia, I., De Vos, D., Pirnay, J.P. Kidd, T., Reid, D., Manos, J., Klockgether, J., Wiehlmann, L., Tummler, B., McClean, S., Winstanley, C., Developing an international Pseudomonas aeruginosa reference panel, Microbiology Open, 2, 1010-23.

Dias, P.J., Sá-Correia, I., The drug:H+ antiporters of family 2 (DHA2), siderophore transporters (ARN) and glutathione:H+ antiporters (GEX) have a common evolutionary origin in hemiascomycete yeasts, BMC Genomics, 14: 901.

Di Lorenzo, F., Silipo, A., Lanzetta, R., Fazio, L.L., Paciello, I., Coutinho, C.P., Sá-Correia, I., Bernardini. M., Molinaro, A., 2013, Structural elucidation and biological activity of the lipooligosaccharide of a Burkholderia dolosa isolate from a cystic fibrosis patient. ChemBioChem, 14(9): 1105-15 .

Eusébio, N., Coutinho, C., Sá-Correia, I., Araújo, R., 2013, SNaPBcen: a novel and practical tool for genotyping Burkholderia cenocepaciaJournal of Clinical Microbiology, 51(8): 2646-53.

Lourenço, A.B., Roque, F.C., Teixeira, M.C., Ascenso, J.R., Sá-Correia, I., Quantitative 1H-NMR-metabolomics reveals extensive metabolic reprogramming and the effect of the aquaglyceroporin FPS1 in ethanol-stressed yeast cells, PLOS One, 8(2): e55439.

Madeira, A., dos Santos, A.C., Santos, P.M., Coutinho, C.P., Tyrrell, J., McClean, S., Callaghan, M., Sá-Correia, I., Proteomic profiling of Burkholderia cenocepacia clonal isolates with different virulence potential retrieved from a cystic fibrosis patient during chronic lung infection, PLOS ONE 8(12): e83065.

Remy, E., Cabrito, T.R., Baster, P., Batista, R.A., Teixeira, M.C., Friml, J., Sá-Correia, I., Duque, P., 2013, A Major Facilitator Superfamily Transporter Plays a Dual Role in Polar Auxin Transport and Drought Stress Tolerance in Arabidopsis, The Plant Cell, 25: 901-26.

2012

Palma, M., Madeira, S.C, Mendes-Ferreira, A., Sá-Correia, I., Impact of assimilable nitrogen availability in glucose uptake kinetics in Saccharomyces cerevisiae during alcoholic fermentation, Microbial Cell Factories, 11: 99.

Teixeira, M.C., Godinho, C.P., Cabrito, T.R., Mira, N.P., Sá-Correia, I., Increased expression of the yeast multidrug resistance ABC transporter Pdr18 leads to increased ethanol tolerance and ethanol production in high gravity alcoholic fermentation, Microbial Cell Factories, 11, 98.

Guerreiro, J.F., Mira, N.P., Sá-Correia, I., Adaptive response to acetic acid in the highly resistant yeast species Zygosaccharomyces bailii revealed by quantitative proteomics. PROTEOMICS, 12: 2303-18.

Madeira; A., da Silva; C.L., Dos Santos, F., Camafeita, E., Cabral, J.M.S., Sá-Correia, I.,  Human Mesenchymal Stem Cell Expression Program upon Extended Ex-Vivo Cultivation, as Revealed by 2-DE-Based Quantitative Proteomics. PLoS ONE, 7(8), e43523 .

dos Santos, S.C., Mira, N.P., Moreira, A.S., Sá-Correia, I., Quantitative- and phospho-proteomic analysis of the yeast response to the tyrosine kinase inhibitor imatinib. OMICS: A Journal of Integrative Biology, 16: 537-51.

dos Santos, S.C., Teixeira, M.C., Cabrito, T.R., Sá-Correia, I., Yeast Toxicogenomics: genome-wide responses to chemical stresses with impact in Environmental Health, Pharmacology and Biotechnology. Frontiers in Genetics, 3, 63.

Remy, E., Cabrito, T.R., Baptista, R., Teixeira, M.C., Sá-Correia, I., Duque, P., The Pht1;9 transporter mediates inorganic Pi acquisition by the Arabidopsis thaliana root during phosphorus starvation. The New Phytologist, 195, 356–371.

2011

Mira, N.P., Madeira, A., Moreira, A.S., Coutinho, A.P., Sá-Correia, I., Genomic expression analysis reveals strategies of Burkholderia cenocepacia to adapt to the airways of cystic fibrosis patients and antimicrobial therapy . PLOS One, 6(12), e28831.

Pereira, F.B., Guimarães, P.M.R, Gomes, D.G., Mira, N.P., Teixeira, M.C., Sá-Correia, I., Domingues, L., Identification of candidate genes for yeast engineering to improve bioethanol production in Very-High-Gravity and lignocellulosic biomass industrial fermentations. Biotechnology for Biofuels, 4, 57.

Coutinho, C.P., dos Santos, S.C., Madeira, A., Mira, N.P., Moreira, A.S., Sá-Correia, I., Long-term colonization of the cystic fibrosis lung by Burkholderia cepacia complex bacteria: epidemiology, clonal variation and genome-wide expression alterations. Frontiers in Cellular and Infection Microbiology, 1, 12.

dos Santos, S.C., Sá-Correia, I., A genome-wide screen identifies yeast genes required for protection against or enhanced cytotoxicity of the antimalarial drug quinine. Molecular Genetics and Genomics, 286(5-6), 333-46.

Gonçalves, J.P., Francisco, A.P., Mira, N.P., Teixeira, M.C., Sá-Correia, I., Oliveira, A.L., Madeira, S.C., TFRank: Network-based prioritization of regulatory associations underlying transcriptional responses. Bioinformatics, 27, 3149-3157.

Cabrito, T.R., Teixeira, M.C., Singh, A., Prasad, R., Sá-Correia, I., The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance. Biochemical Journal, 440, 195-202.

Rocha, J., Popescu, A.O., Borges, P., Mil-Homens, D., Moreira, L.M., Sá-Correia, I., Fialho, A.M., Frazão, C., Burkholderia cenocepacia UDP-glucose dehydrogenase (BceC) structure and role of the Tyr10 in the final hydrolysis of UGDs thioester intermediate. Journal of Bacteriology, 193, 3978-87.

Monteiro, P.T., Dias, P.J., Ropers, D., Oliveira, A.L., Sá-Correia, I., Teixeira, M.C., Freitas, A.T., Qualitative modeling and formal verification of the FLR1 gene mancozeb response in Saccharomyces cerevisiaeIET Systems Biology, 5, 308-16.

Coutinho, C.P., de Carvalho, C.C.C.R., Madeira, A., Pinto-de-Oliveira, A., Sá-Correia, I., Burkholderia cenocepacia phenotypic clonal variation during three and a half years of residence in the lungs of a cystic fibrosis patient. Infection and Immunity, 79, 2950-2960.

Teixeira M.C., Mira N.P., Sá-Correia I., A genome-wide perspective on the response and tolerance to food-relevant stresses in Saccharomyces cerevisiaeCurrent Opinion in Biotechnology, 22, 150-156 (abstract).

Mira, N.P., Henriques, S., Keller, G., Teixeira, M.C., Matos, R., Arraiano, C., Winge, D.R., Sá-Correia, I., Identification of a DNA binding site for the transcription factor Haa1p, required forSaccharomyces cerevisiae response to acetic acid stress. Nucleic Acids Research, 16, 6898-907.

Madeira, A., Santos, P.M., Coutinho, C.P., Pinto-de-Oliveira, A., Sá-Correia, I., Quantitative proteomics (2-D-DIGE) reveals molecular strategies employed by Burkholderia cenocepacia to adapt to the airways of cystic fibrosis patients under antimicrobial therapy. PROTEOMICS, 11, 1313-28.

Teixeira, M.C., Cabrito, T.R., Hanif, Z.M., Vargas, R.C., Tenreiro, S., Sá-Correia, I., Yeast response and tolerance to polyamine toxicity involving the drug:H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4. Microbiology, 157, 945-956

Abdulrehman D., Monteiro P.T., Teixeira M.C., Mira N.P., Lourenço A.B., dos Santos S.C., Cabrito T.R., Francisco A., Madeira S.C., Santos R., Oliveira, A.L., Sá-Correia I., Freitas A. T., “YEASTRACT: Providing a programmatic access to curated transcriptional regulatory associations in Saccharomyces cerevisiae through a web services interface. Nucleic Acids Research39, D136-140

Lourenço A.B., Ascenso J.R., Sá-Correia I., Metabolic insights into the yeast response to propionic acid based on high resolution 1H NMR spectroscopy. Metabolomics, 7, 457-468.

2010

Sá-Correia I., Teixeira M.C., Two-dimensional Electrophoresis-based Expression Proteomics: a microbiologist’s perspective. Expert Reviews in Proteomics, 7(6), 943-953, 2010

Mira, N.P., Palma, M., Guerreiro, J., Sá-Correia I., Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acid. Microbial Cell Factories, 9:79 (abstract)

Dias J.P., Seret M.L., Goffeau A., Sá-Correia I., Baret P., “Evolution of the 12-spanner drug:H+ antiporter DHA1 family in hemiascomycete yeasts.” OMICS: A Journal of Integrative Biology, 14(6):701-10.

Mira, N.P., Teixeira, M.C., Sá-Correia, I., “Characterization of complex regulatory networks and identification of promoter regulatory elements in yeast: in silico and wet-lab", In: Methods in Molecular Biology – Transcriptional Regulation: Methods and Protocols (Springer Ed) (in press)

Teixeira M.C., Dias P.J., Monteiro P.T., Sala A., Oliveira A.L., Freitas A.T., Sá-Correia I., Refining current knowledge on the yeast FLR1 regulatory network by combined experimental and computational approaches. Molecular Biosystems, 6(12), 2471-2481

Mira N.P., Becker J.D., Sá-Correia I., Genomic expression program involving the Haa1p-regulon in Saccharomyces cerevisiae response to acetic acid. OMICS: a Journal of Integrative Biology, 14(5), 587-601, 2010 (abstract)

Mira N.P., Teixeira M.C., Sá-Correia I., Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae : a genome-wide view. OMICS: a Journal of Integrative Biology, 14(5), 525-540, 2010 (abstract)

Roma-Rodrigues, P.M. Santos, D. Benndorf, E. Rapp, I. Sá-Correia, Response ofPseudomonas putidaKT2440 to phenol at the level of membrane proteome, Journal of Proteomics73(8): 1461-1478

Madeira, M.C. Teixeira, I. Sá-Correia, A.L. Oliveira, “Identification of Regulatory Modules in Time Series Gene Expression Data using a Linear Time Biclustering  Algorithm”, IEEE/ACM Transactions on Computational Biology and Bioinformatics,7: 153-165, 2010

Rocha, A.T. Granja, I. Sá-Correia, A.M. Fialho, C. Frazão, 2009, “Cloning, expression, crystallization and preliminary crystallographic studies of UgdG, and UDP-glucose dehydrogenase fromSphingomonas elodeaATCC 31461" Acta Crytallographica. Section F, Structural Biology and Crystallization Communications (in press)

M.C. Teixeira, L.R. Raposo, M. Palma, I. Sá-Correia, 2010, “Identification of genes required for maximal tolerance to high-glucose concentrations, as those present in industrial alcoholic fermentation media, through a chemogenomics approach", OMICS: A Journal of Integrative Biology, 14(2), 201-210, 2010

P.J. Dias, M.C. Teixeira, J.P. Telo, I. Sá-Correia, 2010, “Insights into the mechanisms of toxicity and tolerance to the agricultural fungicide mancozeb in yeast, as suggested by a chemogenomic approach", OMICS: A Journal of Integrative Biology, 14(2), 211-227, 2010

2009

P.M. Santos, I. Sá-Correia, 2009,  “Adaptation to β-myrcene catabolism in Pseudomonas sp. M1: an expression proteomics analysis", PROTEOMICS, 9, 5101–5111, 2009 (abstract)

C. dos Santos, S. Tenreiro, M. Palma,J. Beckerand I. Sá-Correia, “Transcriptomic profiling of the yeast response to quinine evidenced a glucose limitation response attributable to drug-induced inhibition of glucose uptake”, Antimicrobial Agents and Chemotherapy , 53, 5213-5223, 2009 (abstract)

M.C. Teixeira, L.R. Raposo, N.P. Mira, A.B. Lourenço and I. Sá-Correia, “Genome-wide identification of genes required for maximal tolerance to ethanol in yeast: important role of FPS1", Appl. Environ. Microbiol.75: 5761-5772, 2009

M.C. Teixeira, P.M. Santos, C. Rodrigues, I. Sá-Correia, “Teaching Expression Proteomics: from the wet-lab to the laptop”, Biochemistry and Molecular Biology Education37, 279-286, 2009

C.P. Coutinho, I. Sá-Correia, J.A. Lopes,  2009, “Use of Fourier transform infrared spectroscopy and chemometrics to discriminate clinical isolates of bacteria of the Burkholderia cepaciacomplex from different species and ribopatterns", Analytical and Bioanalytical Chemistry, 394(8); 2161-2171, 2009

T.R. Cabrito, M.C. Teixeira, A.A. Duarte, P. Duque, I. Sá-Correia, “Heterologous expression of a Tpo1 homolog from Arabidopsis thaliana confers resistance to the herbicide 2,4-D and other chemical stresses in yeast", Applied Microbiology and Biotechnology84, 927-936, 2009

S.C. Madeira, M.C. Teixeira, I. Sá-Correia and A.L. Oliveira, “Identification of Regulatory Modules in Time Series Gene Expression Data using a Linear Time Biclustering Algorithm", IEEE/ACM Transactions on Computational Biology and Bioinformatics, 21 Mar 2008.  IEEE Computer Society Digital Library. IEEE Computer Society, 22 March 2008http://doi.ieeecomputersociety.org/10.1109/TCBB.2008.34.

S.C. dos Santos, I. Sá-Correia, Genome-wide identification of genes required for yeast growth under imatinib stress: vacuolar H+-ATPase function is an important target of this anticancer drug, OMICS: A Journal of Integrative Biology, 13: 185-198, 2009

V.M.F. Gonçalves, A. Reis, M.R.M. Domingues, J.A. Lopes-da-Silva, A.M. Fialho, L.M. Moreira, I. Sá-Correia, M.A. Coimbra, Structural analysis of gellans produced by Sphingomonas elodeastrains by electrospray tandem mass spectrometry, Carbohydrate Polymers 77, 10-19, 2009

N.P. Mira, A. Lourenço, A. Fernandes, J. Becker, I. Sa-Correia, The RIM101 pathway has a role in Saccharomyces cerevisiae adaptive response and resistance to propionic acid and other weak acids, FEMS Yeast Research,  9, 202-216, 2009 (abstract)

Sá-Correia, S.C. dos Santos, M.C. Teixeira, T.R. Cabrito, N.P. Mira, “Drug:H+ antiporters in chemical stress response in yeast".Trends in Microbiology,17, 22-31, 2009 (abstract)

P.M. Santos, T. Simões, I. Sá-Correia, “Insights into yeast adaptive response to the agricultural fungicide mancozeb: a toxicoproteomics approach", PROTEOMICS1919, 657-670, 2009 (abstract)

2008

A.M. Fialho, L.M. Moreira, A.T. Granja, A.O. Popescu, K. Hoffmann, I. Sá-Correia,  Occurrence, production and applications of gellan: current state and perspectives. Appl Microbiol Biotechnol79, 889-900, 2008 (abstract)

M.C. Teixeira, P.J. Dias,  T. Simões, I. Sá-Correia. “Yeast adaptation to mancozeb involves the up-regulation of FLR1 under the coordinate control of Yap1, Rpn4, Pdr3 and Yrr1” Biochemical Biophysical Research Communications367, 249-255, 2008 (abstract)

Monteiro, N. Mendes, M.C. Teixeira, S. d’Orey, S. Tenreiro, N.P. Mira, H. Pais, A. Francisco, A. Carvalho, A.R. Lourenço, I. Sá-Correia, A.L. Oliveira, A.T. Freitas. “YEASTRACT-DISCOVERER: new tools to improve the analysis of transcriptional regulatory associations inSaccharomyces cerevisiae".Nucleic Acids Res. Database Issue 36: D132-D136, 2008 (abstract)

J.H. Leitão, S.A. Sousa, M.V. Cunha, M.J. Salgado, J. Melo-Cristino, M.C. Barreto and I. Sá-Correia. “Variation of the antimicrobial susceptibility profiles of Burkholderia cepacia complex clonal isolates obtained from chronically infected  cystic fibrosis patients: a five-year survey in the major Portuguese treatment center". European Journal of Clinical Microbiology & Infectious Diseases, 27, 1101-1111, 2008 (abstract)

2007

P.M. Santos, I. Sá-Correia (2007), “Characterization of the unique organization and co-regulation of a gene cluster required for phenol and benzene catabolism in Pseudomonas sp. M1".  Journal of Biotechnology131, 371-378, 2007  (abstract)

A.T. Granja, A. Popescu, A.R. Marques, I. Sá-Correia, A.M. Fialho, “Biochemical characterization and phylogenetic analysis of UDP-glucose dehydrogenase from the gellan gum producer Sphingomonas elodea ATCC  31461" Applied Microbiology and Biotechnology, 2007 (accepted for  publication)

S.A. Sousa, M. Ulrich, A. Bragonzi, M. Burke, D. Worlitzch, J.H. Leitão, C. Meisner, L. Eberl, I. Sá-Correia, G. Döring, “Virulence of Burkholderia cepacia complex strain in gp91phox-/- mice", Cellular Microbiology9, 2817-2825, 2007(in press) (abstract)

Aragão, A.M. Fialho, A.R. Marques, E.P. Mitchell, I. Sá-Correia, C. Frazão, “The complex ofSphingomonas elodeaATCC 31461 Glucose-1-phosphate uridylyltransferase with glucose-1-phosphate reveals a novel quaternary structure, unique among Nucleoside Diphosphate-sugar pyrophosphorylase members", Journal of Bacteriology, 189, 4520–4528, 2007 (abstract)

M.C. Teixeira, P. Duque, I. Sá-Correia “Environmental Genomics: mechanistic insights into toxicity of and resistance to the herbicide 2,4-D", Trends in Biotechnology25: 363-370, 2007 (abstract)

M.V. Cunha, A. Pinto-de-Oliveira, L. Meirinhos-Soares, M.J. Salgado, J. Melo-Cristino, S. Correia, C. Barreto, I. Sá-Correia “Exceptionally high representation of Burkholderia cepacia among B. cepacia complex isolates recovered from the Major Portuguese Cystic Fibrosis Center", Journal of Clinical Microbiology45, 1628–1633, 2007 (abstract)

P.M. Santos,  V. Roma, D. Benndorf, M. von Bergen, H. Harms, I. Sá-Correia (2007) “Mechanistic insights into the global response to phenol in the phenol-biodegrading strain Pseudomonas sp. M1, revealed by quantitative proteomics", OMICS: A Journal of Integrative Biology11:233-251, 2007 (abstract)

R.C. Vargas, R. García-Salcedo, S. Tenreiro, M.C. Teixeira , A.R. Fernandes, J. Ramos and I. Sá-Correia , “Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine-stressed cells" Eukaryotic Cell6, 134-142, 2007(abstract)

S.A. Sousa, L.M. Moreira, J. Wopperer, L. Eberl, I. Sá-Correia, J.H. Leitão, “The Burkholderia cepacia bceA gene encodes a protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities", Biochemical and Biophysical Research Communications353, 200-206, 2007 (abstract)

A.S. Ferreira, J.H. Leitão, S.A. Sousa, A.M. Cosme, I. Sá-Correia, L.M. Moreira “Functional Analysis of Burkholderia cepacia bceD and bceF Genes  Encoding a Phosphotyrosine Phosphatase and a Tyrosine Autokinase: Role in Exopolysaccharide Biosynthesis and Biofilm Formation", Applied and Environmental Microbiology73, 524-534, 2007 (abstract)

2006

Alenquer, S. Tenreiro, I. Sá-Correia. 2006.Adaptive response to the antimalarial drug artesunate in yeast involves Pdr1p/Pdr3p-mediated transcriptional activation of the resistance determinants TPO1 and PDR5.FEMS Yeast Research, 6, 1130-1139, 2006 (abstract)

Simões, N.P. Mira, A.R. Fernandes, I. Sá-Correia, “TheSPI1gene, encoding a glycosylphosphatidylinositol (GPI)-anchored cell wall protein, plays a prominent role in the development of yeast resistance to lipophilic weak acids food preservatives", Applied and Environmental Microbiology72, 7168-7175, 2006 (abstract)

N.D. Mendes, A.C. Casimiro, P.M. Santos, I. Sá-Correia , A.L. Oliveira, A.T. Freitas, “MUSA: A parameter free algorithm for the identification of biologically significant motifs”, Bioinformatics22, 2996-3002, 2006  (abstract)

M.C. Teixeira, P. Monteiro, P. Jain, S. Tenreiro, A.R. Fernandes, N.P. Mira, M. Alenquer, A.T. Freitas, A.L. Oliveira, I. Sá-Correia, “The YEASTRACT database: a tool for the analysis of transcriptional regulatory associations in Saccharomyces cerevisiae“, Nucleic Acids Research, Database Issue34, D446-D451, 2006 (abstract)

Aragão, A.R. Marques, C. Frazão, F.J. Enguita, M.A. Carrondo, A.M. Fialho, I. Sá-Correia, E.P. Mitchell, “Cloning, expression, purification, crystallization and preliminary structure determination of glucose-1-phosphate uridylytransferase (UgpG) fromSphingomonas elodeaATCC 31461 bound to glucose-1-phosphate", Acta CrystallographicaF62, 930-934, 2006 (abstract)

M.C. Teixeira, A.R. Fernandes, N.P. Mira, J.D. Becker, I. Sá-Correia, “Early transcriptional response of Saccharomyces cerevisiae to stress imposed by the herbicide 2,4-dichlorophenoxyacetic acid", FEMS Yeast Research, 6, 230–248, 2006 (abstract)

2005

A.R. Fernandes, N.P. Mira, R.C. Vargas, I. Canelhas, I. Sá-Correia, “Saccharomyces cerevisiae adaptation to weak acids involves the transcription factor Haa1p and of Haa1p-regulated genes”, Biochemical and Biophysical Research Communications337, 95-103, 2005 (abstract)

P.A. Videira, A.P. Garcia, I. Sá-Correia, “Functional and topological analysis of the Burkholderia cenocepacia priming glucosyltransferase BceB, involved in the biosynthesis of the cepacian exopolysaccharide, Journal of Bacteriology187, 5013-5018, 2005 (abstract)

Silva, A.R. Marques, A.M. Fialho, A.T. Granja, I. Sá-Correia, “Proteins Encoded bySphingomonas elodeaATCC 31461 rmlA and ugpG genes, involved in gellan gum biosynthesis, exhibit both dTDP- and UDP-Glucose pyrophosphorylase activities”, Applied and Environmental Microbiology, 71, 4703-4712, 2005 (abstract)

C.A. Viegas, M.G. Cabral, M.C. Teixeira, G. Neumann, H.J. Heipieper, I. Sá-Correia, Yeast adaptation to 2,4-dichlorophenoxyacetic acid involves increased membrane fatty acid saturation degree and decreased OLE1 transcription, Biochemical and Biophysical Research Communications330: 271-278, 2005

Strino, A. Nahmany, J. Rosen, G.J.L. Kemp, I. Sá-Correia, P-G Nyholm, “Conformation of theexo-polysaccharice foBurkholderia cepacia predicted with molecular mechanics (MM3) using genetic algorithm search", Carbohydrate Research340, 1019-1024, 2005 (abstract)

M.C.Teixeira, P.M. Santos, A.R. Fernandes, I. Sá-Correia, “A proteome analysis of yeast responses to the herbicide 2,4-dichlorophenoxyacetic  acid", Proteomics, 5, 1889-1901, 2005 (abstract).

Tenreiro, R.C. Vargas, M.C. Teixeira, C. Magnani, I. Sá-Correia, “The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinat of resistance to quinidine, barban, cisplatin and bleomycin",Biochemical and Biophysical Research Communications,327, 952-959, 2005.

2004

L.M. Moreira, K. Hoffmann, H. Albano, A. Becker, K. Niehaus and I. Sá-Correia, “The gellan gum biosynthetic  genes gelC and gel E encode two separate polypeptides homologous to the activator and the kinase domains of tyrosine autokinases", Journal of Molecular Microbiology and Biotechnology8, 43-57, 2004 (abstract)

M.C. Teixeira, J.P. Telo, N.F. Duarte, I. Sá-Correia , “The herbicide 2,4-dichlorophenoxyacetic acid induces the generation of free-radicals and associated oxidative stress responses in yeast", Biochemical and Biophysical Research Communications324, 1101-1107, 2004 (abstract)

M.V. Cunha, S.A. Sousa, J.H. Leitão, L.M. Moreira, P.A. Videira, I. Sá-Correia, “Studies on the involvement of the exopolysaccharide produced by cystic fibrosis-associated isolates of the Burkholderia cepacia complex in biofilm formation and in persistence of respiratory infections", Journal of Clinical Microbiology42, 3052-3058, 2004 (abstract)

P.M. Santos, D. Benndorf, I. Sá-Correia, “Insights in Pseudomonas putida KT2440 response to phenol-induced stress by quantitative proteomics" Proteomics4, 2640-2652, 2004 (abstract)

R.C. Vargas, S. Tenreiro, M.C. Teixeira, A.R. Fernandes, I. Sá-Correia, “Saccharomyces cerevisiae multidrug transport Qdr2p (Yil121wp): localization and function as a quinidine resistance determinant", Antimicrobial Agents and Chemotherapy, 48, 2531-2537, 2004 (abstract)

M.G. Cabral,  I. Sá-Correia, C.A. Viegas, “Adaptative responses in yeast to the herbicide 2-methyl-4-chlorophenoxyacetic acid at the level of intracellular pH homeostasis", Journal of Applied Microbiology96, 603-612, 2004 (abstract)

Sá-Correia, “Integrating metabolism and genomics”, Conference Report ASM,FEMS Yeast Research,5, 307-311, 2004

Silva, A.M. Fialho, I. Sá-Correia, R.G. Burns, L.J. Shaw, “Combined bioaugmentation and biostimulation to clean-up soil contaminated with high concentrations of atrazine",Environmental Science and Technology,38, 632-637, 2004 (abstract)

Papaefthimiou, M.G. Cabral, C. Mixailidou, C.A. Viegas, I. Sá-Correia, G. Theophilidis, “Comparison of two screening bioassays, based on the frog sciatic nerve and yeast cells, for the assessment of herbicide toxicity",Environmental Toxicology and Chemistry,23, 1211-1218, 2004  (abstract)

2003

L.M. Moreira,  P.A. Videira, S.A. Sousa, J.H. Leitão, M.V. Cunha, I. Sá-Correia,  “Identification and physical organization  of the gene cluster involved in the biosynthesis of Burkholderia cepaciacomplex exopolysaccharide", Biochemical and Biophysical Research Communications312, 323-333, 2003 (abstract)

A.R. Fernandes, P.J. Durão, P.M. Santos, I. Sá-Correia, “Activation and significance of vacuolar H+-ATPase in Saccharomyces cerevisiae adaptation and resistance to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D)", Biochemical and Biophysical Research Communications312, 1317-1324, 2003 (abstract)

M.V. Cunha, J.H. Leitão, E. Mahenthiralingam, P. Vandamme, L. Lito, C. Barreto, M.J. Salgado, I. Sá-Correia, “Molecular analysis of Burkholderia cepacia complex isolates from a Portuguese cystic fibrosis center: a seven-year study", Journal of Clinical Microbiology41, 4113-4120, 2003 (abstract)

Sist, P. Cescutti ,  S. Sveerlavaj, R. Urbani,  J.H. Leitão,  I. Sá-Correia, R. Rizzo, “Macromolecular and solution properties of Cepacian: the exopolysaccharide produced by a strain ofBurkholderia cepaciaisolated from a cystic fibrosis patient", Carbohydrate Research338, 1861-1867, 2003 (abstract)

I.M. Tavares, J.H. Leitão, I. Sá-Correia , “Chromosomal organization and transcription analysis of genes in the vicinity of Pseudomonas aeruginosa glmM gene encoding phosphoglucosamine mutase", Biochemical and Biophysical Research Communications302, 363-371, 2003 (abstract)

A.R. Marques, P.M. Coutinho, P. Videira, A.M. Fialho, I. Sá-Correia, “Sphingomonas paucimobilis b-glucosidase Bgl1: a member of a new bacterial subfamily in family 1 of glycoside hydrolases", Biochemical Journal, 370,793-804, 2003 (abstract)

A.R.Marques, P.B. Ferreira, I.Sá-Correia, A.M. Fialho, “Characterization of the ugpG gene encoding a UDP-glucose pyrophosphorylase from the gellan gum producer Sphingomonas paucimobilisATCC 31461", Molecular Genetics and Genomics268, 816-824, 2003 (abstract)

Videira , Fialho A.M., Marques A.R., Coutinho P.M., Sá-Correia I., “Cloning and sequence analysis of the ces 10 gene encoding aSphingomonas paucimobilisesterase", Applied Microbiology and Biotechnology61, 517-522, 2003 (abstract)

A.R. Fernandes, I. Sá-Correia, “Transcription patterns of PMA1 and PMA2 genes and activity of plasma membrane H+-ATPase in Saccharomyces cerevisiae during diauxic growth and stationary phase", Yeast20, 207-219, 2003 (abstract)

M.G. Cabral, C.A. Viegas, M.C. Teixeira and I. Sá-Correia, “Toxicity of chlorinated phenoxyacetic acid herbicides in the experimental eukaryotic model Saccharomyces cerevisiae: role of pH and of growth phase and size of the yeast cell population", Chemosphere51, 47-54, 2002 (abstract)

2002

Felder, E. Bogengruber,  S. Tenreiro, A.Ellinger, I. Sá-Correia, P. Briza , “Dtr1p, a multidrug resistance transporter of the major facilitator superfamily, plays an essential role in spore wall maturation inSaccharomyces cerevisiae“,Eukaryotic Cell1, 799-810, 2002 

I.Sá-Correia, A. M. Fialho,  P.Videira, L. M. Moreira , A. R. Marques, Albano H., “Gellan gum biosynthesis in Sphingomonas paucimobilis ATCC 31461: genes, enzymes and exopolysaccharide production  engineering", Journal of Industrial Microbiology and Biotechnology29, 170-176, 2002

I.Sá-Correia , S.Tenreiro , “The multidrug resistance transporters of the major facilitator superfamily, six years after disclosure of Saccharomyces cerevisiae genome sequence", Journal of Biotechnology98, 215-226, 2002

F.M.C. Santanta , T. Pinto , A.M. Fialho , I. Sá-Correia ,  J.Empis, “Bacterial removal of quinolizidine alkaloids and other carbon sources from a Lupinus albus aqueous extract”, Journal of Agricultural and Food Chemistry50, 2318-2323, 2002 (abstract)

Tenreiro,  P.A.Nunes, C.A. Viegas, M.S. Neves, M.C. Teixeira, M.G. Cabral, I. Sá-Correia, “AQR1gene (ORF YNL065w) encodes a plasma membrane transporter of the Major Facilitator Superfamily that confers Resistance to Short-chain Monocarboxylic Acids and Quinidine in Saccharomyces cerevisiae”, Biochemical and Biophysical Research Communications292, 741-748, 2002 (abstract)

C. Teixeira and I. Sá-Correia,  “Saccharomyces cerevisiaeresistance to chlorinated phenoxyacetic acid herbicides involves Pdr1p–mediated transcriptional activation ofTPO1 and PDR5 genes", Biochemical Biophysical Research Communications292, 530-537, 2002 (abstract)

2001

Papers in International peer-reviewed Journals – Year 2001

P.A.Videira, A.M. Fialho, R.A. Geremia, C. Breton, I. Sá-Correia, “Biochemical characterisation of ß1-4 glucuronosyltransferase GelK in the gellan gum producing strain Sphingomonas paucimobilis ATCC31461", Biochemical Journal358, 457-464, 2001 (abstract)

M.G. Cabral, C.A. Viegas, I. Sá-Correia, “Mechanisms underlying the acquisition of resistance to octanoic-acid-induced-death following exposure of Saccharomyces cerevisiae to mild stress imposed by octanoic acid or ethanol", Archives of Microbiology175, 301-307, 2001 (abstract)

P.A. Nunes, S. Tenreiro, I. Sá-Correia, “Resistance and adaptation to quinidine in Saccharomyces cerevisiae: role of QDR1 gene (ORF YIL120w), encoding a plasma membrane transporter of the Major Facilitator Superfamily required for multidrug resistance", Antimicrobial Agents and Chemotherapy45, 1528-1534, 2001 (abstract)

Tenreiro, A.R. Fernandes, I. Sá-Correia, “Transcriptional activation of FLR1 gene during Saccharomyces cerevisiaeadaptation to growth with benomyl: role of Yap1 and Pdr3p", Biochemical and Biophysical Research Communications280, 216-222, 2001 (abstract)

R. Fernandes and I. Sá-Correia, “The activity of plasma membrane H+-ATPase is strongly stimulated during Saccharomyces cerevisiaeadaptation to growth under higher copper stress accompanying intracellular acidification", Yeast18, 511-521, 2001 (abstract)

2000

Book Chapters

Sá-Correia and A.M. Fialho, “Electrotransformation of Sphingomonas paucimobilis“, in Electrotransformation of Bacteria, Lab Manual (N. Eynard and J. Teissie, eds), Springer-Verlag, Heidelberg, 2000

Sá-Correia, “A Família das Pseudomonaceae e o Género Pseudomonas“, in Microbiologia, vol. II (Wanda F.C. Ferreira and João Carlos F. De Sousa, eds.), Lidel Edições Técnicas, 123-136, 2000

Papers in International peer-reviewed Journals – Year 2000

J.A. Richau, J.H. Leitão and I. Sá-Correia, “Enzymes leading to the nucleotide sugar precursors for exopolysaccharide synthesis in Burkholderia cepacia“, Biochemical and Biophysical Research Communications276, 71-76, 2000 (abstract)

B.S. Abdallah, T. Simões, A.R. Fernandes, J. Strauss, B. Seiboth, I. Sá-Correia and C.P. Kubicek, “Glucose does not activate the plasma-membrane-bound-H+-ATPase but affects pmaA transcript abundance in Aspergillus nidulans“, Archives of Microbiology174, 340-345, 2000 (abstract)

Tenreiro, P.C. Rosa, C.A. Viegas and I. Sá-Correia, “Expression of AZR1 gene (ORF YGR224w), encoding a plasma membrane transporter of the Major Facilitator Superfamily, is required for adaptation to acetic acid and resistance to azoles in Saccharomyces cerevisiae“, Yeast16, 1469-1481, 2000 (abstract)

I.M. Tavares, L. Jolly, F. Pompeo, J.H. Leitão, A.M. Fialho, I. Sá-Correia and D. Mengin-Lecreulx, “Identification of the Pseudomonas aeruginosa glmM gene encoding phosphoglucosamine mutase", Journal of Bacteriology182, 4453-4457, 2000 (abstract)

Cescutti, M. Bosco, F. Picotti, G. Impalloment, J.H. Leitão, J. Richau and I. Sá-Correia, “Structural study of the exopolysaccharide produced by a clinical isolate of Burkholderia cepacia“,Biochemical and Biophysical Research Communications273, 1088-1094, 2000 (abstract)

Richau, J.H. Leitão, M. Correia, L. Lito, M.J. Salgado, C. Barreto, P. Cescutti and I. Sá-Correia, “Molecular typing and exopolysaccharide biosynthesis of Burkholderia cepaciaisolates from a Portuguese Cystic Fibrosis Center",Journal of Clinical Microbiology38, 1651-1655, 2000 (abstract)

Videira, L.L. Cortes, A.M. Fialho and I. Sá-Correia, “Identification of the pgmGgene, encoding a bifunctional protein with phosphoglucomutase and phosphomannomutase activities, in the gellan gum producing strain Sphingomonas paucimobilisATCC 31461", Applied and Environmental Microbiology66, 2252-2258, 2000 (abstract)

A.R. Fernandes, M. Prieto and I. Sá-Correia, “Modification of plasma membrane lipid order and H+-ATPase activity as part of the response of Saccharomyces cerevisiae to cultivation under mild and high copper stress", Archives of Microbiology173, 262-268, 2000 (abstract)

1999

Papers in International peer-reviewed Journals – Year 1999

I.M. Tavares, J.H. Leitão, A.M. Fialho and I. Sá-Correia, “Pattern of changes in the activity of enzymes of GDP-D-mannuronic acid synthesis and in the level of transcription of algAalgC and algDgenes accompanying the loss and emergence of mucoidy in Pseudomonas aeruginosa“, Research in Microbiology 150, 105-116, 1999 (abstract)

R. Fernandes and I. Sá-Correia, “Comparative effects of Saccharomyces cerevisiaecultivation under copper stress on the activity and kinetic parameters of plasma-membrane-bound H+-ATPases PMA1 and PMA2", Archives of Microbiology171, pp 273-278, 1999 (abstract)

A.M. Fialho, L.O. Martins, M-L. Donval, J.H. Leitão, M.J. Ridout, A.J. Jay, V.J. Morris and I. Sá-Correia, “Structures and properties of gellan polymers produced by Sphingomonas paucimobilisATCC 31461 from lactose compared with those produced from glucose and from cheese whey", Applied and Environmental Microbiology65, 2485-2491, 1999 (abstract) 

Chambel, C.A. Viegas and I. Sá-Correia, “Effect of cinnamic acid on the growth and on plasma membrane H+-ATPase activity of Saccharomyces cerevisiae“, International Journal of Food Microbiology50, 173-179, 1999 (abstract)

Brôco, S. Tenreiro, C.A. Viegas and I. Sá-Correia, “FLR1gene (ORF YBR008c) is required for benomyl and methotrexate resistance in Saccharomyces cerevisiaeand its benomyl-induced-expression is dependent on Pdr3 transcriptional regulator", Yeast15, 1595-1608,1999 (abstract)

1998

Papers in International peer-reviewed Journals – Year 1998

Carmelo V., Santos R., Viegas C.A. and Sá-Correia I., Modification of Saccharomyces cerevisiae thermotolerance following rapid exposure to acid stress, International Journal of Food Microbiology42, 225-230, 1998 (abstract)

Fernandes A.R., Peixoto F.P. and Sá-Correia I., Activation of the H+-ATPase in the plasma membrane of cells of Saccharomyces cerevisiae grown under mild copper stress, Archives of Microbiology171, 6-12, 1998 (abstract)

Jay A.J., Colquhoun I.J., Ridout M.J., Brownsey G.J., Morris V.J., Fialho A.M., Leitão J.H. and Sá-Correia I., Analysis of structure and function of gellans with different substitution patterns, Carbohydrate Polymers35, 179-188, 1998 (abstract)

Lopes J.P., Menezes J.C., Faster Development of Fermentation Processes. Early Stages Process Diagnostics.  AIChE Symposium Series, vol. 94, n. 320, pp. 391-396, 1998.

Lupi F.M., Fernandes H.M.L. and Sá-Correia I., Increase of copper toxicity to growth of Chlorella vulgaris with increase of light intensity, Microbial Ecology35, 193-198, 1998 (abstract)

Monteiro G.A. and Sá-Correia I., In vivo activation of yeast plasma membrane H+-ATPase by ethanol: effect on the kinetic parameters and involvement of the carboxyl-terminus regulatory domain, Biochimica et Biophysica Acta1370, 310-316, 1998 (abstract)

Viegas C.A., Almeida P.F., Cavaco M. and Sá-Correia I., The H+-ATPase in the plasma membrane of Saccharomyces cerevisiae is activated during growth latency in octanoic acid-supplemented medium following the decrease in intracellular pH and cell viability, Applied and Environmental Microbiology64, 779-783, 1998 (abstract)

1997

Books

Sá-Correia, A.M. Fialho and C.A. Viegas, “Microbial Response to Stress: what’s new and how can it be applied" (Abstract Book of an Euroconference, Sesimbra, 15 – 18 March, 1997), Gráfica Povoense Ltd, Póvoa de Santa Iria, Portugal, pp.140, 1997

Papers in International peer-reviewed Journals – Year 1997

J.H. Leitão and I. Sá-Correia, “Oxygen-dependent up-regulation of transcription of alginate genes, algAalgC and algD, in Pseudomonas aeruginosaResearch in Microbiology148, 37-43, 1997. (abstract)

C.A. Viegas and I. Sá-Correia, “Effects of low temperatures (9-33°C) and pH (3.3-5.7) in the loss of Saccharomyces cerevisiae viability by combining lethal concentrations of ethanol with octanoic and decanoic acids", International Journal of Food Microbiology34, 267-277, 1997. (abstract)

J.A. Richau, D. Choquenet, A.M. Fialho, L.M. Moreira and I. Sá-Correia, “The Biosynthesis of the Exopolysaccharide Gellan Results in the Decrease of Sphingomonas paucimobilis Tolerance to Copper (Cu2+)", Enzyme and Microbial Technology20, 510-515, 1997. (abstract)

Carmelo, H. Santos, and I. Sá-Correia, “Effect of extracellular acidification on the activity of plasma membrane ATPase and on the cytosolic and vacuolar pH of Saccharomyces cerevisiae,"Biochimica Biophysica Acta1325, 63-70, 1997.(abstract)

J.H. Leitão and I. Sá-Correia, “Effect of growth-inhibitory concentrations of copper on alginate biosynthesis in highly mucoid Pseudomonas aeruginosa“, Microbiology, 143, 481-488, 1997. (abstract)

J.A. Richau, D.Choquenet, A.M. Fialho and I. Sá-Correia, “Emergence of Cu++-tolerant mutants defective in gellan synthesis in Cu++-stressed cultures of Sphingomonas paucimobilis“, Research in Microbiology148, 251-261, 1997. (abstract)

Carmelo and I. Sá-Correia, “HSP26 gene transcription is strongly induced during Saccharomyces cerevisiaegrowth at low pH", FEMS Microbiology Letters149, 85-88, 1997.(abstract)

M. Moreira, M. S. da Costa and I. Sá-Correia, “Comparative genomic analysis of isolates belonging to the six species of the genus Thermususing pulsed-field gel electrophoresis and ribotyping" Archives of Microbiology,168, 92-101, 1997. (abstract)

L.M. Moreira and I. Sá-Correia, “Megaplasmids in Thermus oshimai isolates from two widely separated geographical areas: restriction fragment profiling and DNA homology", Archives of Microbiology168, 473-479, 1997 (abstract)

1996

Papers in International peer-reviewed Journals – Year 1996

Carmelo V., Bogaerts P. and Sá-Correia I., Activity of Plasma Membrane H+-ATPase and Expression of PMA1 and PMA2 Genes in Saccharomyces cerevisiae Cells Grown at Optimal and Low pH, Archives of Microbiology , 166, 315-320, 1996. (abstract)

Leitão J.H., Alvim T. and Sá-Correia I., Ribotyping of Pseudomonas aeruginosa Isolates from Patients and Water Springs and Genome Fingerprinting of Variants concerning Mucoidy, FEMS Immunology and Medical Microbiology13, 287-292, 1996. (abstract)

Martins L.O., Fialho A.M., Rodrigues P.L. and Sá-Correia I., Gellan Gum Production and Activity of Biosynthetic Enzymes in Sphingomonas paucimobilis Mucoid and Non-mucoid Variants, Biotechnology and Applied Biochemistry24, 47-54, 1996.(abstract)

Moreira L.M., Nobre M.F., Sá-Correia I. and da Costa M.S., Genomic typing and fatty acid composition of Rhodothermus marinusSystematic and Applied Microbiology19, 83-90, 1996.(abstract)

Rosa M.F. and Sá-Correia I., Intracellular Acidification does not account for Inhibition of Saccharomyces cerevisiae Growth in the Presence of Ethanol, FEMS Microbiology Letters, 135, 271-274, 1996.(abstract)

Santana F.M.C., Fialho A.M., Sá-Correia I. and Empis J.M.A., Isolation of bacterial strains capable of using lupanine, the predominant quinolizidine alkaloid in white lupin, as sole carbon and energy source", Journal of Industrial Microbiology , 17, 110-115, 1996.(abstract)

1995

Papers in International peer-reviewed Journals – Year 1995

Carmelo V., Bogaerts P. and Sá-Correia I., Effects of extracellular acidification on the activity of yeast plasma membrane H+-ATPase and expression of PMA1 and PMA2 genes, Yeast (special issue), 11, S426, 1995 (abstract)

Leitão J.H. and Sá-Correia I., Growth-phase-dependent Alginate Synthesis, Biosynthetic Enzymes and Expression of Alginate Genes in Pseudomonas aeruginosaArchives of Microbiology163, 217-222, 1995 (abstract)

Moreira L.M., da Costa M.S. and Sá-Correia I., Plasmid RFLP Profiling and DNA Homology in Thermus isolated from Hot Spring of Different Geographical Areas, Archives of Microbiology164, 7-15,1995.(abstract)

Rosa M.F., Viegas C.A. and Sá-Correia I., Toxicity of ethanol and octanoic acid and the intracellular acidification in Saccharomyces cerevisiaeYeast (special issue), 11, S592, 1995 (abstract)

Viegas C.A. and Sá-Correia I., Toxicity of Octanoic Acid in Saccharomyces cerevisiae at Temperatures between 8.5 and 30°C, Enzyme and Microbial Technology17, 826-831, 1995 (abstract)

Viegas C.A., Sebastião P.B., Nunes A.G. and Sá-Correia I., Activation of Plasma Membrane H+-ATPase and Expression of PMA1 and PMA2 Genes in Cells of Saccharomyces cerevisiae Grown at Supra-optimal Temperatures, Applied and Environmental Microbiology61, 1904-1909, 1995.(abstract)

Viegas C.A., Sebastião P.B., Nunes A.G. and Sá-Correia I., Activation of Plasma Membrane H+-ATPase and Expression of PMA1 and PMA2 Genes in Yeast Cells of Grown at Supra-optimal Temperatures, Yeast (special issue), 11, S465, 1995

1994

Book Chapters

J.H. Leitão, A.M. Fialho and I. Sá-Correia, “Manipulation of Alginate and Gellan Gum pathways in Pseudomonas aeruginosa or Pseudomonas elodea by Recombinant DNA Technology" in: Progress in Biotechnology, vol. 9, (L. Alberghina, L. Frontali and P. Sensi, eds.), Elsevier Science Publishers, Amsterdam, pp. 831-834, 1994

Papers in International peer-reviewed Journals – Year 1994

C.A. Viegas, P. Supply, E. Capieux, L. van Dyck, A. Goffeau and I. Sá-Correia. “Regulation of the Expression of the H+-ATPase Genes PMA1 and PMA2 during Growth and Effects of Octanoic Acid in Saccharomyces cerevisiae“, Biochimica Biophysica Acta, (Gene Structure & Expression) 1217, 74-80, 1994. (abstract)

F.M. Lupi, H.M.L. Fernandes, M.M. Tomé, I. Sá-Correia and J.M. Novais, “Influence of the Nitrogen Source and Photoperiod on Exopolysaccharide Synthesis by the Microalga Botryococcus braunii“, Enzyme and Microbial Technology16, 546-550, 1994. (abstract)

M.F. Rosa and I. Sá-Correia, “Limitations to the Use of Extracellular Acidification for the Assessment of Plasma Membrane H+-ATPase Activity and Ethanol Tolerance in Yeasts", Enzyme and Microbial Technology16, 808-812, 1994. (abstract)

L.O. Martins and I. Sá-Correia, “Temperature Profiles of Gellan Gum Synthesis and Activities of Biosynthetic Enzymes", Biotechnology and Applied Biochemistry20, 385-395, 1994.(abstract)

G.A. Monteiro, P. Supply, A. Goffeau and I. Sá-Correia, “The in vivo Activation of Saccharomyces cerevisiae Plasma Membrane H+-ATPase by Ethanol Depends on the Expression of the PMA1 Gene but not of PMA2 Gene", Yeast10, 1439-1446, 1994.(abstract)

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