Research Topics

  • Food and beverage spoilage by yeasts
  • Adaptive response and tolerance to acetic acid in the highly acetic acid tolerant food spoilage yeast species Zygosaccharomyces bailii
  • Alcoholic fermentation processes carried out by conventional or non-conventional yeast species
  • Saccharomyces cerevisiae adaptive responses and tolerance to acetic acid in industrial fermentation media, in particular wine fermentation and lignocellulosic hydrolysates fermentation for the production of second generation bioethanol
  • Comparative and Functional Genomics
  • Yeast transcriptional regulation
  • S. cerevisiae adaptive responses and tolerance nitrogen limitation in industrial fermentation media
  • Sugar transport in Saccharomyces species and its involvement in response and adaptation to alcoholic fermentation stresses

Selected Publications

Palma M, Münsterkötter M, Peça J, Güldener U and Sá-Correia I (2017) Genome sequence of the highly weak-acid-tolerant Zygosaccharomyces bailii IST302, amenable to genetic manipulations and physiological studies, Fems Yeast Res, 17(4)

Palma M, Dias PJ, Roque FC, Luzia L, Guerreiro JF, Sá-Correia I (2017), The Zygosaccharomyces bailii transcription factor Haa1 is required for acetic acid and copper stress responses suggesting subfunctionalization of the ancestral bifunctional protein Haa1/Cup2, BMC Genomics, 18(1):75

Palma M, Madeira S C, Mendes-Ferreira A e Sá-Correia I (2012) Impact of assimilable nitrogen availability in glucose uptake kinetics in Saccharomyces cerevisiae during alcoholic fermentation. Microb cell fact. 11(1):99

Mira NP, Palma M, Guerreiro JF and Sá-Correia I (2010) Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acid. Microb Cell Fact. 9(1):79

Palma M, Goffeau A, Spencer-Martins I and Baret PV (2007) A phylogenetic analysis of the Sugar Porters in hemiascomycetous yeasts, J Mol Microbiol Biotechnol 12 (3-4): 241-248

All Papers

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Papers in international journals

Antunes M, Palma M, Sá-Correia I (2018) Transcriptional profiling of Zygosaccharomyces bailii early response to acetic acid or copper stress mediated by ZbHaa1, Scientific Reports, accepted for publication.

Palma M, Guerreiro JF, Sá-Correia I (2018) Adaptive response and tolerance to acetic acid in Saccharomyces cerevisiae and Zygosaccharomyces bailii: a physiological genomics perspective. Front Microbiol, 9:274.

Teixeira MC, Monteiro PT, Palma M, Costa C, Godinho CP, Pais P, Cavalheiro M, Antunes M, Lemos A, Pedreira T and Sá-Correia I (2018) YEASTRACT: an upgraded database for the analysis of transcription regulatory networks in Saccharomyces cerevisiae, Nucleic Acids Res, 46(D1):D348-D353.

Palma M, Münsterkötter M, Peça J, Güldener U and Sá-Correia I (2017) Genome sequence of the highly weak-acid-tolerant Zygosaccharomyces bailii IST302, amenable to genetic manipulations and physiological studies, Fems Yeast Res, 17(4).

Palma M, Dias PJ, Roque FC, Luzia L, Guerreiro JF, Sá-Correia I (2017) The Zygosaccharomyces bailii transcription factor Haa1 is required for acetic acid and copper stress responses suggesting subfunctionalization of the ancestral bifunctional protein Haa1/Cup2, BMC Genomics, 18(1):75 (Recommended by Carol Mackintosh and David E.K. Ferrier, 2017, F1000Prime)

Palma M, Roque FC, Guerreiro JF, Mira NP, Queiroz L and Sá-Correia I (2015) Screening of a genomic library from a Zygosaccharomyces bailii-derived interspecies hybrid strain to search for genes responsible for its remarkably high acetic acid tolerance. BMC Genomics. 16(1):1070

Mira NP, Münsterkötter M, Dias-Valada F, Santos J, Palma M, Roque FC, Guerreiro JF, Rodrigues F, Sousa MJ, Leão C, Güldener U e Sá-Correia I (2014). The genome sequence of the highly acetic acid-tolerant Zygosaccharomyces bailii-derived interspecies hybrid strain ISA1307, isolated from a sparkling wine plant. DNA Res. 21(3): 299-313

Teixeira MC, Monteiro PT, Guerreiro JF, Gonçalves JP, Mira NP, Dos Santos SC, Cabrito TR, Palma M, Costa C, Francisco AP, Madeira SC, Oliveira AL, Freitas AT e Sá-Correia I (2013) The YEASTRACT database: an upgraded information system for the analysis of gene and genomic transcription regulation in Saccharomyces cerevisiae. Nucleic Acids Res. 42(1):D161-6

Palma M, Madeira S C, Mendes-Ferreira A e Sá-Correia I (2012) Impact of assimilable nitrogen availability in glucose uptake kinetics in Saccharomyces cerevisiae during alcoholic fermentation. Microb cell fact. 11(1):99

Mira NP, Palma M, Guerreiro JF and Sá-Correia I (2010) Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acid. Microb Cell Fact. 9(1):79

Teixeira M, Santos L, Palma M and Sá-Correia I (2009) Identification of genes required for maximal tolerance to high-glucose concentrations. OMICS. 14 (2): 201-210

Dos Santos SC, Tenreiro S, Palma M, Becker J and Sá-Correia I (2009) Transcriptomic profiling of the yeast response to quinine evidenced a glucose limitation response attributable to drug-induced inhibition of glucose uptake. Antimicrob Agents and Chemother. 53(12): 5213-5223

Palma M, Seret M-L and Baret PV (2009) Combined phylogenetic and neighbourhood analysis of the hexose transporters and glucose sensors in yeasts. FEMS Yeast Res. 9(4): 526-534

Palma M, Goffeau A, Spencer-Martins I and Baret PV (2007) A phylogenetic analysis of the Sugar Porters in hemiascomycetous yeasts, J Mol Microbiol Biotechnol 12 (3-4): 241-248

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