In progress

MIXED-UP – Targeting pathogenesis and engineering cell factories: by developing mixed regulatory-metabolic genomic models in yeasts

Principal investigator: Miguel Cacho Teixeira
Contract: PTDC/BII-BIO/28216/2017
Start date: 01/10/2018
Duration: 36 months

LactoCan – Exploring the interference between Candida spp. and lactobacilii to foster the development of non-conventional
antifungal therapies

Principal investigator: Nuno P Mira
Contract: PTDC/BIA-MIC/31515/20
Start date: 01/10/2018
Duration: 36 months

The BioData.pt Research Infrastructure (workpackage YEASTRACT+)

Principal investigator at IST: Isabel Sá-Correia
Contract: LISBOA-01-0145-FEDER-022231
Start date: 01/07/2017
Duration: 36 months

CNCVir – The coding and noncoding virulome of Burkholderia cenocepacia

Principal investigator: Jorge Humberto Leitão
Contract: PTDC/MAR-BIO/1547/2014
Start date: 01/04/2016
Duration: 36 months

Harnessing the power of the microbial metamobilome: using marine sponges as models to uncover novel biotechnological appliances from symbiont communities

Principal investigator: Rodrigo da Silva Costa
Contract: PTDC/MAR-BIO/1547/2014
Start date: 01/07/2016
Duration: 36 months

Structural and functional analysis of the Haa1 transcription factor required for yeast response and resistance to acetic acid

Principal investigator at IST: Isabel Sá-Correia
Contract: PTDC/BBB-BEP/0385/2014
Start date: 01/05/2016
Duration: 36 months

Molecular and Mechanical Forces in Biology measured with Force Feedback Microscopy

Principal investigator at IST: Isabel Sá-Correia
Contract: PTDC/FIS-NAN/6101/2014
Start date: 01/05/2016
Duration: 36 months

CANTROL – Deciphering the mechanisms of transcriptional regulation that control antifungal drug resistance in the pathogenic yeast Candida glabrata: aiming the development of improved diagnosis and therapeutic approaches

Principal investigator: Miguel Cacho Teixeira
Contract: PTDC/BBB-BIO/4004/2014
Start date: 01/03/2016
Duration: 36 months

SMARTWINE – Smarter wine fermentations: integrating Omic-tools for the development of novel mixed-starter cultures for tailored-made wine production

Principal investigator at IST: Nuno P Mira
Contract: PTDC/AGR-TEC/3315/2014
Start date: 01/05/2016
Duration: 36 months

TTRAFFIC – Toxicity and Transport for Fungal
Production of Industrial Compounds 

Principal investigator at IST: Nuno P Mira
Contract:ERA-IB-2-6/0003/2014
Start date: 01/04/2016
Duration: 36 months

Concluded

MFS-stress-Major Facilitator Superfamily transporters in the context of modern agriculture constraints: exploratory studies

Principal investigator at IST: Isabel Sá-Correia
Contract: EXPL/AGR-PRO/1013/2013
Start date: 01/01/2014
Duration: 12 months

PhysBioFFM – Biological physics atudies based on Force Feedback Microscopy

Principal investigator at IST: Isabel Sá-Correia
Contract: EXPL/FIS-NAN/1395/2013
Start date: 01/01/2014
Duration: 12 months

PANCANDIDA – Towards the development of novel diagnosis tools for the early detection of invasive infections caused by C. albicans and C. glabrata

Principal investigator: Nuno P Mira
Contract: Gilead Génese Program
Start date: 01/01/2014
Duration: 24 months

Immunomics-Bcc: Exploitation of immunogenic proteins of the Burkholdeira cepacia complex to design new diagnostic and therapeutic strategies

Principal investigator: Sílvia Sousa
Contract: PTDC/BBB-BIO/1958/2012
Start date: 01/04/2013
Duration: 36 months

KINASE-Phosphoproteomics in Burkholderia to assess the role of tyrosine phosporylation in virulence determinants expression

Principal investigator: Leonilde Moreira
Contract: PTDC/QUI-BIQ/118260/2010
Start date: 01/01/2012
Duration: 36 months

FUNDRING: Identification of new biomarkers for antifungal drug resistance diagnosis in Candida glabrata: the particular role of multidrug resistance transporters

Principal investigator: Miguel Cacho Teixeira
Contract: PTDC/EBB-BIO/119356/2010
Start date: 01/01/2012
Duration: 36 months

TerbAzineBiorem – Studies on the efficacy and scale-up of bioremediation strategies for soils contaminated with the herbicide terbuthylazine

Principal investigator: Cristina Anjinho Viegas
Contract: PTDC/AAC-AMB/111317/2009
Start date: 01/01/2011
Duration: 36 months

ROOT-INT – Role of a two-component regulatory system in the early interaction between Sinorhizobium meliloti and plant root hairs

Principal investigator: Leonilde M Moreira
Contract: PTDC/BIA-MIC/111733/2009
Start date: 01/01/2011
Duration: 36 months

Bacterial protein azurin as a new candidate drug to treat untreatable breast cancers

Principal investigator: Arsénio M Fialho
Contract: PTDC/EBB-BIO/100326/2009
Start date: 01/01/2011
Duration: 36 months

Exploiting the type II phosphomannose isomerase BseAJ as a new target for the development of new antimicrobials and biotechnological applications

Principal investigator: Jorge H Leitão
Contract: PTDC/EBB-BIO/098352/2008
Start date: 01/01/2010
Duration: 36 months

ZygoSacAR – Mechanistic insights into acetic acid resistance in food spoilage yeasts: from the experimental model Saccharomyces cerevisiae to Zygosaccharomyces species

Principal Investigator: Isabel Sá-Correia
Contract: PTDC/AGR-ALI/102608/2008
Start date: 01/04/2010
Duration: 36 months

QCMTF – Biosensor platform for transcription factor DNA binding activity detection

Principal Investigator at IST: Isabel Sá-Correia
Contract: PTDC/ EBB-EBI/108517 /2008
Start date: 01/04/2010
Duration: 36 months

Resistance to pesticides and other chemical stresses of agricultural interest: role of plant Major Facilitator Superfamily transporters

Principal Investigator at IST: Isabel Sá-Correia
Contract: PTDC/AGR-AAM/102967/2008
Start date: 01/04/2010
Duration: 36 months

Imatinib Resistance and Targets in Chronic Myeloid Leukaemia: Post-Genomic Approaches using Yeast as Model System

Principal Investigator: Isabel Sá-Correia
Contract: PTDC/SAU-FCF/71760/2006
Start date: 01/01/2008
Duration: 36 months

Characterization and modeling of a specific transcriptional regulatory network required for multidrug resistance in yeast.

Principal Investigator: Isabel Sá-Correia
Contract: PTDC/BIO/72063/2006
Start date: 01/01/2008
Duration: 36 months

Functional and biochemical analysis of the yeast multidrug resistance transporters Qdr2 and Aqr1

Principal Investigator: Miguel Cacho Teixeira
Contract: PTDC/BIA-MIC/72577/2006
Start date: 01/06/2008
Duration: 36 months

ARN – Algorithms for the identification of Genetic Regulatory Networks

Principal Investigator of the IST team: Isabel Sá-Correia
Contract: PTDC/EIA/67722/2006
Start date: 01.01.2008
Duration: 36 months

Dyablo: models for the dynamic behaviour of Biological Networks

Principal Investigator of the IST team: Isabel Sá-Correia
Contract: PTDC/EIA/71587/2006
Start date: 01.01.2008
Duration: 36 months

Optimization and control of intermittent UASB reactors and microbial population dynamics

Principal Investigator of the IST team: Jorge Humberto Leitão
Contract: PTDC/AMB/65025/2006
Start date: 01/01/2008
Duration: 36 months

Development of bioassays for herbicide toxicity based on gene expression profiling using yeast cells (HERBITOXBIOAS)

Principal investigator: Cristina Anjinho Viegas
Contract: PTDC/AMB/64230/2006
Start date: 01/11/2007
Duration: 36 months

Expression profiling studies to specify the symbiotic genetic programme of the model legume Medicago truncatula

Principal Investigator of the IST team: Leonilde Morais Moreira
Contract: PTDC/AGR-GPL/70592/2006
Start date: 01/10/2007
Duration: 36 months

Acute versus persistent infection by Burkholderia cepacia complex bacteria in cystic fibrosis patients: underlying mechanisms, in particular the role of exopolysaccharide biosynthesis

Principal Investigator: Isabel Sá-Correia
Contract: PTDC/SAU-MII/69591/2006
Start date: 01/10/2007
Duration: 36 months

Regulation of exopolysaccharide biosynthesis and virulence of Burkholderia cepacia by protein-tyrosine phosphorylation

Principal Investigator: Leonilde Morais Moreira
Contract: PTDC/BIA-MIC/652 10/2006
Start date: 01/09/2007
Duration: 36 months

Enzymatic Degradation and Synthesis of Azo and Antraquinonic Dyes

Principal Investigator of the IST team: Cristina Anjinho Viegas
Contract: PTDC/BIO/72108/2006
Start date: 01/09/2007
Duration: 36 months

PROBIOETHANOL – Proteomics and engineering of yeast ethanol tolerance for high-productivity bio-ethanol fermentation processes

Principal Investigator of the IST team: Isabel Sá-Correia
Contract: PTDC/BIO/66151/2006
Start date: 01/07/2007
Duration: 36 meses

Herbicide resistance in Arabidopsis thaliana: Role of plant multidrug resistance transporters

Principal Investigator of the IST team: Isabel Sá-Correia
Contract: PTDC/AGR-AAM/67858/2006
Start date: 01/07/2007
Duration: 36 months

Role of the exopolysaccharides in the early steps of Rhizobium-legume symbiosis

Principal Investigator: Leonilde Morais Moreira
Contract: PTDC/AGR-AAM/66977/2006
Start date: 01/03/2007
Duration: 36 months

Biochemical and structural studies of UDP-glucose dehydrogenases

Principal Investigator at IST: Arsénio Mendes Fialho
Contract: PTDC/QUI/67925/2006
Start date: …
Duration: 36 months

Insights into the complex regulatory network acting in yeast cells challenged with drugs/chemical stresses: genome-wide expression approaches supported by bioinformatics

Principal Investigator of the IST team: Isabel Sá-Correia
Contract: PDCT/BIO/56838/2004
Start date: 01/01/2006
Duration: 24 months

Strategies to accelerate atrazine biodegradation in contaminated soils, waters or sediments and assessment of the ecotoxicity of this herbicide and its metabolites (ATRAZINEBIOREM)

Principal Investigator: Arsénio Mendes Fialho
Contract: POCI/AMB/56039/2004
Start date: 01/09/2005
Duration: 36 months

Biosynthesis of the bacterial gum gellan: molecular biology, biochemistry and genetic engineering of the pathway

Principal Investigator: Arsénio Mendes Fialho
Contract: POCTI/BIO/58401/2004
Start date: 01/01/2005
Duration: 36 months

DBYeast: Infrastructure and algorithms for analysis and identification of gene regulatory networks

Principal Investigator of the IST team: Isabel Sá-Correia
Contract: POSI/EIA/57398/2004
Start date: 01/01/2005
Duration: 36 months