Nuno Bernardes

Research Topics

  • Microbial-based therapy of cancer: bacterial protein azurin and derived peptides as novel anticancer agents
  • Cell-based therapies for cancer: expression of azurin in Mesenchymal stem/stromal cells

Selected Publications

N Bernardes, S Abreu, FA Carvalho, F Fernandes, NC Santos, AM Fialho “Modulation of membrane properties of lung cancer cells by azurin enhances the sensitivity to EGFR-targeted therapy and decreased β1 integrin-mediated adhesion” Cell Cycle, 15(11)1415-24 (2016) (DOI: 10.1080/15384101.2016.1172147, 2016

Bernardes N., Ribeiro A. S., Abreu S., Vieira A.F., Carreto L., Santos M., Seruca R., Paredes J., Fialho A.M. “High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin” International Journal of Biochemistry & Cell Biology, 50:1-9, 2014

Bernardes N., Ribeiro A.S., Abreu S., Mota B., Matos R.G., Arraiano C.M., Seruca R., Paredes J., Fialho A.M. “The bacterial protein azurin impairs invasion and FAK/Src signaling in P-cadherin-overexpressing breast cancer cell models”  PLoS One, 8 (7), e69023, 2013

Bernardes N, Chakrabarty AM, Fialho AM. “Engineering of bacterial strains and their products for cancer therapy.” Appl Microbiol Biotechnol. 2013 Jun;97(12):5189-99.

Alternative web pages